BAY-850

Ainm Ceimigeach:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-il)-2-chloro-4-methoxy-5-(5 -((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

Còd SMILES:

ClC(C(C(N[C@H)(CC1=CC=C(C#N)C=C1)CN)CN[C@@H]2CC[C@H)(N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Còd InChi:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35( 39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

iuchair InChi:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Facal-luirg:

BÀS-850; BÀS 850; BHA 850

Solubility:DMSO

Stòradh: 

Tuairisgeul:

“Is e sgrùdadh ceimigeach a th’ ann am BAY-850 airson bromodomain ATAD2A a bhios a’ gluasad peptide H4 acetylated bhon bromodomain ATAD2 le luach IC50 de 20 nM (HTRF). Tha 850 a’ taisbeanadh roghnachas eireachdail thairis air a h-uile bromodomains eile (gun bhuillean ann am BROMOscan aig 10 µM) agus a’ gluasad ATAD2 làn-fhaid bho chromatin ann an ceallan beò aig dùmhlachd de 1 µM mar a chaidh a dhearbhadh le FRAP Gus dùmhlachd buaidhean neo-shònraichte far-targaid de ≥ a sheachnadh Chan eilear a’ moladh 5 µM (http://www.thesgc.org/chemical-probes/BAY-850)"

Targaid: sgrùdadh ceimigeach airson bromodomain ATAD2A