Acid Chenodeoxycholic

Ainm Ceimigeach:

(R) -4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl ) searbhag pentanoic

Còd SMILES:

C[C@@H]([C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4( [H])C[C@H](O)CC[C@]4(C)[C@]3([H])CC[C@]12C)CCC(O)=O

Còd InChi:

InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10- 8-16(25)12-15(23)13 -20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+ ,20-,22+,23+,24-/m1/s1

iuchair InChi:

RUDATBOHQWOJDD-BSWAIDMHSA-N

Facal-luirg:

474-25-9, CAS: 474-25-9, CAS: 474-25-9, Chenodeoxycholic Acid, Antropodeoxycholic acid, Antropodesoxycholic acid, CCRIS 2195, Chendol, chenic acid; Chenix, Chenodeoxycholic acid, Chenodesoxycholic acid, Chenodiol, Gallodesoxycholic acid, NSC 657949, Xenbilox

Solubility:Soluble ann an DMSO, chan ann ann an uisge

Stòradh:Tioram, dorcha agus aig 0 - 4 C airson geàrr-ùine (làithean gu seachdainean) no -20 C airson ùine fhada (mìosan gu bliadhnaichean)

Tuairisgeul:

Tha Chenodiol, ris an canar cuideachd Chenodeoxycholic Acid agus chenocholic acid, na searbhag bile. Tha e a’ nochdadh mar stuth geal criostalach nach gabh a sgaoileadh ann an uisge ach a tha soluiteach ann an alcol agus searbhag acetic, le puing leaghaidh aig 165-167 ° C. Canar chenodeoxycholates ri salainn den searbhag carboxylic seo. Chaidh searbhag Chenodeoxycholic a chleachdadh mar leigheas meidigeach gus clachan gall a sgaoileadh. Faodar searbhag Chenodeoxycholic a chleachdadh ann an làimhseachadh xanthomatosis cerebrotendineous. Tha a’ chompanaidh bith-theicneòlas Astràilianach Giaconda air deuchainn a dhèanamh air làimhseachadh airson galar Hepatitis C a bhios a’ cothlamadh searbhag chenodeoxycholic le bezafibrate.

Targaid: Gabhadair niùclasach gnìomhaichte FXR