BAY598 R-isomer
Mion-fhiosrachadh toraidh
Bathar Tags
| Meud pacaid | Ri fhaotainn | Prìs (USD) |
| 50mg | Anns a’ bhùth | Faigh cuòt |
| 250mg | Anns a’ bhùth | Faigh cuòt |
| 500mg | Anns a’ bhùth | Faigh cuòt |
Ainm Ceimigeach:
(R, E) -N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol- 4-yl) -N-ethyl-2-hydroxyacetamide
Còd SMILES:
CCN([C@@H]1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3)=N/C# N)C(CO)=O
Còd InChi:
InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22 ( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m1/s1
iuchair InChi:
OTTJIRVZJJGFTK-GOSISDBHSA-N
Facal-luirg:
BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer
Solubility:DMSO
Stòradh:
Tuairisgeul:
Is e BAY-598 R-isomer an R-isomer aig BAY589. Faodar BAY-598 R-isomer a chleachdadh mar stuth iomraidh. Tha BAY-598 na probe ceimigeach làidir, farpaiseach peptide airson SMYD2. Tha cemotype sònraichte aig BAY-598 an coimeas ris an sgrùdadh ceimigeach SMYD2 gnàthach LLY-507. Tha BAY-598 a’ cur bacadh air methylation in vitro de p53K370 le IC50 = 27 nM agus tha barrachd air taghadh 100-fhillte thairis air histone methyltransferases eile agus targaidean neo-epigenetic eile. Tha BAY-598 a’ cur bacadh air methylation p53K370 ann an ceallan le IC50<1 µM. (A bharrachd air an seo, tha feartan aig BAY-598 a tha co-chosmhail ri deuchainnean in vivo.) Chaidh todhar smachd, BAY-369, a leasachadh cuideachd. Tha BAY-369 a’ cur bacadh air methylation in vitro de p53K370 le IC50 >70 micromolar.
Targaid:
