Adavivint

Ainm Ceimigeach:

N-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3 -methylbutanamide

Còd SMILES:

CC(C) CC(NC1=CC(C2=CC3=C(NN=C3C(N4)=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C=C2)=CN= C1)=o

Còd InChi:

InChI=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28( 37-36-24)29-34-25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9- 16H,8H2,1-2H3,(H,33,38)(H,34,35)(H,36,37)

iuchair InChi:

AQDWDWAYVBQMAM-UHFFFAOYSA-N

Facal-luirg:

Adavivint, SM04690, SM-04690, SM 04690, 1467093-03-3

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).

Tuairisgeul:

Neach-dìon slighe beag moileciuil Wnt le EC50 de 3 nM in vitro; ag adhbhrachadh eadar-dhealachadh hMSC a-steach do chondrocytes aibidh, gnìomh agus a’ lughdachadh ìrean comharran catabolic cartilage; a’ leasachadh gu mòr sgòran histology Comann Rannsachaidh Osteoarthritis Eadar-nàiseanta (OARSI) agus bith-chomharran ann am modail OA creimich.

Targaid: WNT