NTN21277

የኬሚካል ስም

(2S,4R)-1-((S)-2-(3-(3-2-(5-(5-(4-(3-ክሎሮ-4-ፍሎሮፊኒል))አሚኖ))-7-methoxyquinazolin-6-yl) ኦክሲሲ) ፔንትል) ኦክሲሲ) ethoxy) ፕሮፓናሚዶ)-3,3-ዲሜቲልቡታኖይል)-4-ሃይድሮክሲ-ኤን- (4--ሜቲልቲያዞል-5-yl) ቤንዚል) ፒሮሊዲን-2-ካርቦክሳይድ

የፈገግታ ኮድ፡-

O=C([C@H]1N(C([C@@H])(NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4))N=CN=C3C=C2OC =O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C(C)N=CS6)C=C5

የኢንቺ ኮድ

InChi=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57) 26-56(38)46(60)43(47(2፣3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9- 14፣21፣23-24፣27-28፣33፣38፣43፣57H፣6-8፣15-20፣22፣25-26H2፣1-5H3፣(H፣50፣59)(H፣55፣ 58)(H,51,52,54)/t33-,38+,43-/m1/s1

የኢንቺ ቁልፍ፡

NICKHWYZMNLEPJ-TZSMONEZSA-N

ቁልፍ ቃል፡

Gefitinib ላይ የተመሠረተ PROTAC 3; NTN21277; NTN-21277; ኤን.ቲ.ኤን 21277

መሟሟት; 

ማከማቻ፡ 

መግለጫ፡-

NTN21277፣ እንዲሁም Gefitinib-based PROTAC 3 በመባል የሚታወቀው የ EGFR እና EGFR ሚውታንቶችን ከዲሲ50 ከ11.7 nM እና 22.3 nM ለHCC827 ሴል (ኤክስዮን 19 ዴል) እና ኤች3258R (L) እና ኤች 3258አር ሴል) የሚያመጣ የVHL ምልመላ PROTAC ነው።

ዒላማ: EGFR