I-DEL-22379

I-DEL-22379
  • Igama:I-DEL-22379
  • Inombolo yekhathalogi:Idatha ye-CPDB3713
  • Inombolo ye-CAS:181223-80-3
  • Isisindo se-Molecular:444.55
  • I-Chemical Formula:I-C26H28N4O3
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Usayizi Wephakethe Ukutholakala Intengo (USD)
    100mg Kukhona kusitoki 350
    250mg Kukhona kusitoki 600
    1g Kukhona kusitoki 1200
    Osayizi abengeziwe Thola Izingcaphuno Thola Izingcaphuno

    Igama Lekhemikhali:

    (Z)-N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide

    Ikhodi ye-SMILES:

    O=C(NC1=CC2=C(NC(/C2=C/C3=CNC4=C3C=C(OC)C=C4)=O)C=C1)CCN5CCCCC5

    Ikhodi ye-InChi:

    I-InChI=1S/C26H28N4O3/c1-33-19-6-8-23-20(15-19)17(16-27-23)13-22-21-14-18(5-7-24(21) 29-26(22) 32)28-25(31)9-12-30-10-3-2-4-11-30/h5-8,13-16,27H,2-4,9-12H2,1H3,(H,28 ,31)(H,29,32)/b22-13+

    I-InChi Key:

    I-INQUULXCZAKMS-LPYMAVHISA-N

    Igama elingukhiye:

    DEL-22379, DEL22379, DEL 22379, 181223-80-3

    Ukunyibilika:I-Soluble ku-DMSO

    Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

    Incazelo:

    I-DEL-22379 iyi-ERK Dimerization inhibitor enamandla futhi ekhethayo. I-DEL-22379 ivimbela i-ERK Dimerization ngaphandle kokuthinta i-ERK phosphorylation, ivimbela i-tumorigenesis eqhutshwa i-RAS-ERK pathway oncogenes. Cishe i-50% yezifo ezibulalayo zabantu zibonisa izimpawu ze-RAS-ERK ezingalawulwa; ukuyivimbela kuyisu elivumelekile lokungenelela kwe-antineoplastic.

    Ithagethi: ERK


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