I-Omarigliptin

Igama Lekhemikhali:

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H -pyran-3-amine

Ikhodi ye-SMILES:

N[C@@H]1[C@@H](C2=CC(F)=CC=C2F)OC[C@H](N3CC4=NN(S(=O)(C)=O)C= C4C3)C1

Ikhodi ye-InChi:

I-InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9) -12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+ ,17-/m1/s1

I-InChi Key:

I-MKMPWKUAHLTIBJ-ISTRZQFTSA-N

Igama elingukhiye:

I-Omarigliptin,MK-3102,MK3102,Marizev,1226781-44-7

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-Omarigliptin, eyaziwa nangokuthi i-MK-3102, iyi-DPP-4 inhibitor enamandla futhi esebenza isikhathi eside ekwelapheni kanye ngeviki uhlobo lwesifo sikashukela sohlobo 2. I-MK-3102 (omarigliptin), ikhonjwe njenge-dipeptidyl peptidase 4 inhibitor (DPP-4) inhibitor enamandla futhi ekhethiwe enephrofayili ye-pharmacokinetic enhle kakhulu evumeleka ekudobeni komuntu kanye ngeviki futhi yakhethwa njengekhandidethi lokuthuthuka emtholampilo. I-Omarigliptin okwamanje isesigabeni sesi-3 sokuthuthuka komtholampilo.

Ithagethi: DPP-4