I-Ertugliflozin

Igama Lekhemikhali:

(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3 , 4-triol

Ikhodi ye-SMILES:

"CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(O3)(CO4)CO)O)O)O)Cl "

Ikhodi ye-InChi:

"I-InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27 )18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18 -,19-,20+,21-,22-/m0/s1 "

I-InChi Key:

"MCIACXAZCBVDEE-CUUWFGFTSA-N"

Igama elingukhiye:

I-Ertugliflozin, PF 04971729,MK-8835,1210344-57-2

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

I-Ertugliflozin, eyaziwa nangokuthi yi-PF-04971729, iyi-inhibitor enamandla futhi ekhethayo ye-sodium-dependent glucose cotransporter 2 kanye nekhandidethi lasemtholampilo ekwelapheni uhlobo 2 sikashukela i-mellitus. Ucwaningo lwasemtholampilo lubonise ukuthi i-Ertugliflozin (1-25 mg / ngosuku) ithuthukise ukulawulwa kwe-glycemic, isisindo somzimba kanye nomfutho wegazi ezigulini ezine-T2DM elawulwa kancane nge-metformin, futhi yabekezelelwa kahle.

Ithagethi: SGLT-2