I-Sitagliptin

I-Sitagliptin
  • Igama:I-Sitagliptin
  • Inombolo yekhathalogi:I-CPDA0100
  • Inombolo ye-CAS:654671-77-9(Sitagliptin Phosphate Monohydrate); 654671-78-0 (Sitagliptin Phosphate ); 486460-32-6(isisekelo samahhala)
  • Isisindo se-Molecular:407.31
  • I-Chemical Formula:I-C16H15F6N5O
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Usayizi Wephakethe Ukutholakala Intengo (USD)

    Igama Lekhemikhali:

    I-Sitagliptin (INN; ngaphambili eyayihlonzwe njenge-MK-0431 futhi idayiswa ngaphansi kwegama lokuhweba i-Januvia) iyisidakamizwa somlomo se-antihyperglycemic (anti-diabetic) sesigaba se-dipeptidyl peptidase-4 (DPP-4) inhibitor.

    Ikhodi ye-SMILES:

    O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O )(O)O.[H]O[H]

    Ikhodi ye-InChi:

    I-InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13(7- 26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1, 2,3,4);1H2/t9-;;/m1../s1

    I-InChi Key:

    GQPYTJVDPQTBQC-KLQYNRQASA-N

    Igama elingukhiye:

    Sitagliptin,Sitagliptin phosphate,Januvia,Glactiv,ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

    Ukunyibilika:I-Soluble ku-DMSO

    Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

    Incazelo:

    I-Sitagliptin (INN; ngaphambili eyayihlonzwe njenge-MK-0431 futhi idayiswa ngaphansi kwegama lokuhweba i-Januvia) iyisidakamizwa somlomo se-antihyperglycemic (anti-diabetic) sesigaba se-dipeptidyl peptidase-4 (DPP-4) inhibitor. Yasungulwa futhi imakethwa ngabakwaMerck & Co. Lo muthi ovimbela i-enzyme usetshenziswa wodwa noma uhlanganiswe namanye ama-ejenti omlomo we-antihyperglycemic (njenge-metformin noma i-thiazolidinedione) ekwelapheni uhlobo 2 lwesifo sikashukela. Inzuzo yalo muthi iwukuthi imiphumela yayo engemihle ephansi (isb., ukwehla kwe-hypoglycemia, ukukhuluphala kancane) ekulawuleni amanani eglucose egazini. I-Exenatide (Byetta) nayo isebenza ngomphumela wayo ohlelweni lwe-incretin.

    Ithagethi: DPP-4


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