JBJ-04-125-02 R-isomer
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
Igama Lekhemikhali:
(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2 -yl) i-acetamide
Ikhodi ye-SMILES:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Ikhodi ye-InChi:
I-InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28(35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8, 11,14-16,26,31,36H,9-10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
I-InChi Key:
VHQVOTINPRYDAO-AREMUKBSSA-N
Igama elingukhiye:
Ukunyibilika:
Isitoreji:
Incazelo:
I-JBJ-04-125-02 iyi-mutant-selective EGFR allosteric inhibitor enomsebenzi ongaba khona wokulwa nomdlavuza. Njenge-ejenti eyodwa, inganqanda ukwanda kwamaseli kanye nokusayina kwe-EGFRL858R/T790M/C797S ku-vitro kanye ne-vivo. Inhlanganisela ye-osimertinib ne-JBJ-04-125-02 iphumela ekwenyukeni kwe-apoptosis, ukuvimbela okuphumelelayo kokukhula kwamaselula, kanye nokusebenza okuthuthukile kwe-vitro kanye ne-vivo uma kuqhathaniswa ne-ejenti eyodwa kuphela.
Ithagethi: EGFR
