I-EAI-045

Igama Lekhemikhali:

2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

Ikhodi ye-SMILES:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Ikhodi ye-InChi:

I-InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8 -27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

I-InChi Key:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Igama elingukhiye:

EAI-045, EAI045, EAI 045, 1942114-09-1

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-EAI045 ia i-EGFR inhbitor enamandla futhi ekhethiwe. I-EAI045 iqondise ukukhetha eziguquguqukayo ezingazweli emuthini ze-EGFR kodwa ivikela isamukeli sohlobo lwasendle. I-EAI045 ivimbela i-L858R/T790M-mutant EGFR enamandla aphansi we-nanomolar ekuhlolweni kwamakhemikhali ezinto eziphilayo.

Ithagethi: EGFR