I-GDC-0326

Igama Lekhemikhali:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)oxy)propanamide

Ikhodi ye-SMILES:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Ikhodi ye-InChi:

I-InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17( 20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

I-InChi Key:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Igama elingukhiye:

I-GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-GDC-0326 iyi-inhibitor enamandla futhi ekhethayo ye-α-Isoform ye-Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). I-GDC-0326 ifinyelela izinga eliphezulu kakhulu lokukhetha ngaphezu kwamanye ama-kinases. I-GDC-0326 ine-plasma CL ephansi kumuntu. Phakathi komndeni we-PI3 kinase, kunama-isoforms ekilasi le-I PI3K (α, β, δ, kanye no-γ). Kulawa ma-isoforms, i-PI3Kα iyona evame ukuhlotshaniswa nomdlavuza.

Ithagethi: PI3K