Zidesamtinib; NVL-520

Orukọ Kemikali:

(6R) -22-ethyl-54-fluoro-42,6-dimethyl-22H,42 H-7-oxa1 (3,5) -pyridina-2 (3,4) -pyrazola-4 (4,5) [1,2,3]triazola5 (1,2) -benzenacycloheptaphan-16-amine

KỌỌDỌ SMILES:

FC1=CC([C@](OC2=C(N=CC3=C2)N)(C)[H]=C(C=C1)C4=NN(N=C4CC5=C3N(N=C5)CC )C

Koodu InChi:

InChi=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9- 17 (16) 12 (2) 31-19-8-14 (21) 10-25-22 (19) 24 / h5-6,8-12H, 4,7H2,1-3H3, (H2,24,25 )/t12-/m1/s1

Bọtini InChi:

DTWUUAFTYSMNQX-GFCCVEGCSA-N

Koko-ọrọ:

2739829-00-4;CAS:2739829-00-4;CAS:2739829-00-4;Zidesamtinib; NVL-520; NVL520; NVL 520

Solubility: 

Ibi ipamọ:Gbẹ, dudu ati ni 0 - 4 C fun igba kukuru (ọjọ si awọn ọsẹ) tabi -20 C fun igba pipẹ (osu si ọdun).

Apejuwe:

Zidesamtinib (NVL-520) jẹ doko, yiyan, ti nṣiṣe lọwọ ẹnu, ati idena ọpọlọ ẹjẹ-ọpọlọ permeable ROS1 idapọ ati inhibitor iyipada resistance.

afojusun: ROS1