Quarfloxin

Quarfloxin
  • Orukọ:Quarfloxin
  • Katalogi No.CPD2205
  • CAS No.:865311-47-3
  • Ìwọ̀n Molikula:604.67
  • Fọọmu Kemikali:C35H33FN6O3
  • Fun iwadi ijinle sayensi nikan, kii ṣe fun awọn alaisan.

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    ọja Tags

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    Orukọ Kemikali:

    5-fluoro-N- (2- ((S)) -1-methylpyrrolidin-2-yl) ethyl -3-oxo-6- ((R) -3- (pyrazin-2-yl) pyrrolidin-1-yl -3H-benzo [b] pyrido [3,2,1-kl] phenoxazine-2-carboxamide

    KỌỌDỌ SMILES:

    FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1

    Koodu InChi:

    InChi=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42 -29-15-21-5-2-3-6-22 (21)16-30 (29)45-34-31 (42)25(33(26)43)17-27 (36)32(34)41-14-9-23 (19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12 ,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23-,24+/m1/s1

    Bọtini InChi:

    WOQIDNWTQOYDLF-RPWUZVVSA-N

    Koko:

    CX 3543; CX-3543; CX 3543; Quarfloxacin

    Solubility: 

    Ibi ipamọ: 

    Apejuwe:

    Quarfloxin, ti a tun mọ ni Quarfloxacin ati CX-3543, jẹ itọsẹ fluoroquinolone pẹlu iṣẹ antineoplastic. Quarfloxin ṣe idalọwọduro ibaraenisepo laarin amuaradagba nucleolin ati igbekalẹ DNA G-quadruplex kan ninu awoṣe ribosomal DNA (rDNA), ibaraenisepo pataki fun biogenesis rRNA ti o pọ ju ninu awọn sẹẹli alakan; idalọwọduro ti DNA G-quadruplex yii: ibaraenisepo amuaradagba ni aberrant rRNA biogenesis le ja si ni idinamọ ti iṣelọpọ ribosome ati apoptosis sẹẹli tumo.

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