Tropifexor
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 100mg | O wa | 800 |
| 1g | O wa | Ọdun 1850 |
| 5g | O wa | 7400 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
2-( (1R, 3r, 5S) -3- ((5-cyclopropyl-3- (2- (trifluoromethoxy) phenyl) isoxazol-4-yl) methoxy) -8-azabicyclo [3.2.1] octan-8- yl) -4-fluorobenzo [d] thiazole-6-carboxylic acid
KỌỌDỌ SMILES:
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C (O)=O)C=C7S6)[C@H](CC5)C4
Koodu InChi:
InChi=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18 (11-16) 39-13-20-24 (35-41-26 (20) 14-5-6-14) 19-3-1-2-4-22 (19) 40-29 (31). 32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
Bọtini InChi:
VYLOOGHLKSNNEK-PIIMJCKOSA-N
Koko-ọrọ:
Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).
Apejuwe:
Tropifexor (compound 1) jẹ aramada ati agonist ti o lagbara pupọ ti FXR pẹlu EC50 ti 0.2 nM. Induction ti o lagbara ti awọn Jiini BSEP ati SHP ni a ṣe akiyesi ni awọn sẹẹli akọkọ nipasẹ Tropifexor ni ọna ti o gbẹkẹle ifọkansi. BSEP induction loke ọkọ (DMSO) iṣakoso ni a ṣe akiyesi ni awọn ifọkansi bi kekere bi 1 nM, lakoko ti o lagbara ti SHP (15-fold loke ọkọ) ni a ṣe akiyesi ni 10 nM ati induction iwonba ti SHP ni 1 nM (3-fold) [1 ].
afojusun: FXR
