PRT-060318; PRT318; P142–76
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 500mg | O wa | 900 |
| 1g | O wa | 1350 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
2-((1R,2S) -2-aminocyclohexyl) amino) -4- (m-tolylamino) pyrimidine-5-carboxamide
KỌỌDỌ SMILES:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
Koodu InChi:
InChi=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22, 23,24) / t14-, 15 + / m0 / s1
Bọtini InChi:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
Koko-ọrọ:
PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)
Apejuwe:
PRT060318 jẹ oludaniloju ti o lagbara ati ti o yan ti spleen tyrosine kinase (Syk; IC50 = 4 nM) . O jẹ aṣayan, idinamọ 92% ti iṣẹ Syk, nigba ti awọn kinases miiran ṣe idaduro> 70% iṣẹ, ni ifọkansi ti 50 nM ni igbimọ ti 270 kinases. PRT060318 ṣe idiwọ ikojọpọ ti o ni idawọle ti pilasima ọlọrọ platelet (IC50 = 2.5 μM) ni vitro ati idilọwọ awọn thrombosis ni awoṣe asin transgenic ti heparin-induced thrombocytopenia. O fa onibaje lymphocytic lukimia (CLL) B cell apoptosis ati idilọwọ awọn yomijade ti chemokines CCL3, CCL4, ati CXCL13.3 PRT060318 tun idilọwọ awọn CLL B cell chemotaxis ati pseudoemperipolesis.
Àfojúsùn: Syk
