BAY 61-3606 2HCl

Orukọ Kemikali:

2-[[7- (3,4-Dimethoxyphenyl) imidazo [1,2-c] pyrimidin-5-yl] amino] -3-pyridinecarboxamide dihydrochloride

KỌỌDỌ SMILES:

O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl

Koodu InChi:

InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24- 14)25-19-13 (18 (21)27)4-3-7-23-19;;/h3-11H,1-2H3, (H2,21,27)(H,23,24,25) ;2*1H

Bọtini InChi:

SPMFEULFGGPQLN-UHFFFAOYSA-N

Koko-ọrọ:

BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

BAY 61-3606 jẹ alagbara (Ki = 7.5 nM) ati oludaniloju yiyan ti Syk kinase. BAY 61-3606 ṣe idilọwọ kii ṣe ibajẹ nikan (awọn iye IC50 laarin 5 ati 46 nM) ṣugbọn tun alalaja ọra ati iṣelọpọ cytokine ninu awọn sẹẹli mast. BAY 61-3606 jẹ imudara gaan ni awọn basophils ti a gba lati awọn koko-ọrọ eniyan ti o ni ilera (IC50 = 10 nM) ati pe o dabi pe o kere ju ni agbara ninu awọn basophils ti a gba lati awọn koko-ọrọ atopic (serum IgE giga) (IC50 = 8.1 nM). Imuṣiṣẹpọ olugba sẹẹli B ati awọn olugba fun apakan Fc ti ami ifihan IgG ni awọn eosinophils ati awọn monocytes tun ni agbara nipasẹ BAY 61-3606.

Àfojúsùn: Syk