PCO371
Alaye ọja
ọja Tags
Iwọn Pack | Wiwa | Iye owo (USD) |
Orukọ Kemikali:
1- (3,5-dimethyl-4- (2-(4-oxo-2------------) phenyl-1,3,8-triazaspiro [4.5] dec-1-en-8-yl sulfonyl) ethyl) phenyl) -5,5-dimethylimidazolidine-2,4-dione.
KỌỌDỌ SMILES:
O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC)=C(OC(F)(F)F) )C=C4)N5)C5=O)=O)C(C)=C2)=O
Koodu InChi:
InChi=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28 (11 -13-36)25 (39)33-23 (35-28)19-5-7-21 (8-6-19)43-29(30,31)32/h5-8,15-16H,9 -14H2,1-4H3,(H,33,35,39)(H,34,38,40)
Bọtini InChi:
LDZJFVOUPUFOHX-UHFFFAOYSA-N
Koko-ọrọ:
PCO371; PCO-371; PCO 371
Solubility:
Ibi ipamọ:
Apejuwe:
PCO371 jẹ agonist PTHR1 ti o lagbara ati yiyan fun itọju hypoparathyroidism. Isakoso ẹnu ti PCO371 si awọn eku osteopenic nfa ilosoke pataki ninu iyipada eegun pẹlu ilosoke opin ni ibi-egungun. Ninu awọn eku hypocalcemic, PCO371 ṣe atunṣe awọn ipele kalisiomu omi ara laisi jijẹ kalisiomu ito, ati pẹlu awọn ipa ti o lagbara ati gigun ju awọn abẹrẹ PTH lọ.
afojusun: PTHR1