AZD7507

Orukọ Kemikali:

4- (2-fluoro-4-methylanilino) -6- [4- (2-hydroxyethyl) piperazin-1-yl] -7-methoxycinnoline-3-carboxamide

KỌỌDỌ SMILES:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

Koodu InChi:

InChi=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31 )20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25, 32) (H,26,27)

Bọtini InChi:

CPDGCAFPSIOTGO-UHFFFAOYSA-N

Koko-ọrọ:

AZD7507; AZD-7507; AZD 7507

Solubility:DMSO

Ibi ipamọ: 

Apejuwe:

AZD7507 jẹ oludaniloju CSF-1R ti o lagbara ati yiyan (iṣẹ ṣiṣe sẹẹli 32 nM), AZD7507 ni a ka si agbo ti o ni ileri bi o ṣe ni idaduro agbara ti o fẹ ati awọn ohun-ini elegbogi oogun ẹnu ti AZ683. Pẹlupẹlu, ninu iwadi telemetry ninu awọn aja ti a fun ni iwọn lilo ẹnu kan, ko si eero inu ọkan ati ẹjẹ, ko si igbega ti troponin ti o ni ibatan si itọju naa, ati pe ko si iyipada ninu ECG.

Àfojúsùn: CSF-1R