BI-3406

Orukọ Kemikali:

N-((R) -1- (3-amino-5- (trifluoromethyl) phenyl) ethyl) -7-methoxy-2-methyl-6- (((S)) -tetrahydrofuran-3-yl) oxy) quinazolin- 4-amin

KỌỌDỌ SMILES:

C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2

Koodu InChi:

InChi=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11- 17)20 (31-3)10-19 (18)29-13 (2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3,(H,28,29 ,30)/t12-,17+/m1/s1

Bọtini InChi:

XVFDNRYZXDHTHT-PXAZEXFGSA-N

Koko-ọrọ:

BI-3406; BI 3406; BI3406

Solubility: 

Ibi ipamọ: 

Apejuwe:

BI-3406 jẹ Agbara & Yiyan SOS1:: KRAS Inhibitor (IC50=5 nM), eyiti o Ṣii Ọna Tuntun fun Itọju Awọn Tumours-KRAS-Iwakọ. BI 3406 yiyan sopọ mọ SOS1 ati dina ibaraenisepo pẹlu KRAS, laibikita iyipada KRAS. BI 3406 nfa RAS GTP ati idinku PERK ati idilọwọ idagbasoke sẹẹli ti awọn laini sẹẹli ti o yipada KRAS, ti o gbe pupọ julọ awọn iyipada KRAS aṣoju (ie G12D, G12V, G13D ati awọn miiran). BI 3406, nigba ti a nṣakoso ni ẹnu si awọn eku ti o ru tumo, o fa iwọn lilo ti o gbẹkẹle ipa aimi tumo ti o le ṣe iyipada si awọn ifasẹyin nigbati o ba ni idapo pẹlu idinamọ MEK1

afojusun: SOS1