BMS-986165

Orukọ Kemikali:

6- (cyclopropanecarboxamido) -4- ((2-methoxy-3- (1-methyl-1H-1,2,4-triazol-3-yl) phenyl) amino) - N- (methyl-d3) pyridazine-3 -carboxamide

KỌỌDỌ SMILES:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]

Koodu InChi:

InChi=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17 (13)31-3)18-22-10-28 (2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23) ,24,25,29)/i1D3

Bọtini InChi:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Koko:

1609392-27-9;CAS:1609392-27-9;CAS:1609392-27-9：BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Solubility:Tiotuka ni DMSO

Ibi ipamọ:Gbẹ, dudu ati ni 0 - 4 C fun igba kukuru (ọjọ si awọn ọsẹ) tabi -20 C fun igba pipẹ (osu si ọdun).

Apejuwe:

BMS-986165 jẹ Agbara Giga ati Inhibitor Allosteric Yiyan ti TYK2. BMS-986165 Awọn bulọọki Il-12, IL-23 ati tẹ I Interferon Signaling ati Pese fun Imudara Agbara ni Awọn awoṣe Preclinical ti Arun Ifun Ifun. MS-986165 ni agbara sopọ mọ agbegbe pseudokinase Tyk2 (Ki = 0.02 nM), ati pe o jẹ yiyan ti o ga julọ lodi si nronu ti 265 kinases ati pseudokinases. Apopọ naa ni agbara ni idinamọ IL-23-, IL-12-, ati Iru I interferon-ìṣó cellular ifihan agbara ati awọn idahun transcriptional (IC50 ibiti o 2-14 nM).

afojusun: TYK2