BAY-850

Orukọ Kemikali:

N-((R) -1-(((1s,4S)-4-aminocyclohexyl) amino) -3- (4-cyanophenyl) propan-2-yl) -2-chloro-4-methoxy-5- (5). (((R) -1- (p-tolyl) ethyl) amino) methyl)furan-2-yl) benzamide

KỌỌDỌ SMILES:

ClC(C(N[C@H](CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Koodu InChi:

InChi=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-3 6(47-32)34-19-33(35(39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-4) 0)9-7-26)22-43-30-14-12-29(41)13-15-30/h4-11,16-17,19-20,25,29-31 ,42-43H,12-15,18,22-23,41H2,1-3H3,(H,44,45)/t25-,29-,30+,31-/m1/s1

Bọtini InChi:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Koko:

BAY-850; BAY850; BAY 850

Solubility:DMSO

Ibi ipamọ: 

Apejuwe:

"BAY-850 jẹ iwadii kemikali fun ATAD2A bromodomain eyiti o yọkuro H4 peptide acetylated lati ATAD2 bromodomain pẹlu iye IC50 ti 20 nM (HTRF). MST ati awọn wiwọn BROMOscan tọkasi Kd ti 84.9 nM ati 120 nM, lẹsẹsẹ B. 850 han olorinrin yiyan lori gbogbo awọn miiran bromodomains (ko si awọn ikọlu ni BROMOscan ni 10 µM) ati nipo ATAD2 ni kikun lati chromatin ninu awọn sẹẹli laaye ni ifọkansi ti 1 µM gẹgẹbi ipinnu nipasẹ FRAP. http://www.thesgc.org/chemical-probes/BAY-850) "

Ifojusi: iwadii kemikali fun ATAD2A bromodomain