Chenodeoxycholic Acid

Orukọ Kemikali:

(R) -4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a] phenanthren-17-yl ) pentanoic acid

KỌỌDỌ SMILES:

C[C @ @ H]([C@H] 1CC[C @] 2([H])[C @] 3([H])[C@H](O)C[C @] 4( [H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)CCC(O)=O

Koodu InChi:

InChi=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10- 8-16 (25) 12-15 (23) 13 -20 (22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+ ,20-,22+,23+,24-/m1/s1

Bọtini InChi:

RUDATBOHQWOJDD-BSWAIDMHSA-N

Koko:

474-25-9, CAS: 474-25-9, CAS: 474-25-9, Chenodeoxycholic Acid, Anthropodeoxycholic acid, Anthropodesoxycholic acid, CCRIS 2195, Chendol, chenic acid; Chenix, Chenodeoxycholic acid, Chenodesoxycholic acid, Chenodiol, Gallodesoxycholic acid, NSC 657949, Xenbilox

Solubility:Tiotuka ni DMSO, kii ṣe ninu omi

Ibi ipamọ:Gbẹ, dudu ati ni 0 - 4 C fun igba kukuru (ọjọ si awọn ọsẹ) tabi -20 C fun igba pipẹ (awọn oṣu si ọdun)

Apejuwe:

Chenodiol, ti a tun mọ ni Chenodeoxycholic Acid ati chenocholic acid, jẹ bile acid. O nwaye bi nkan ti okuta kirisita funfun ti a ko le yanju ninu omi ṣugbọn tiotuka ninu oti ati acetic acid, pẹlu aaye yo ni 165-167 °C. Awọn iyọ ti acid carboxylic yii ni a pe ni chenodeoxycholates. A ti lo Chenodeoxycholic acid gẹgẹbi itọju ailera lati tu awọn gallstones. Chenodeoxycholic acid le ṣee lo ni itọju ti xanthomatosis cerebrotendineous. Ile-iṣẹ imọ-ẹrọ nipa imọ-ẹrọ ti ilu Ọstrelia Giaconda ti ṣe idanwo itọju kan fun ikolu Hepatitis C ti o dapọ chenodeoxycholic acid pẹlu bezafibrate.

Àfojúsùn: FXR olugba iparun ti mu ṣiṣẹ