BAY598 R-isomer
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 50mg | o wa | Gba agbasọ |
| 250mg | o wa | Gba agbasọ |
| 500mg | o wa | Gba agbasọ |
Orukọ Kemikali:
(R, E) -N-(1- (N'-cyano-N---------- 4-yl)-N-ethyl-2-hydroxyacetamide
KỌỌDỌ SMILES:
CCN([C@@H] 1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3)=N/C# N)C(CO)=O
Koodu InChi:
InChi=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H) ,28,29)/t18-/m1/s1
Bọtini InChi:
OTTJIRVZJJGFTK-GOSISDBHSA-N
Koko:
BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer
Solubility:DMSO
Ibi ipamọ:
Apejuwe:
BAY-598 R-isomer jẹ R-isomer ti BAY589. BAY-598 R-isomer le ṣee lo bi agbo-itọka kan. BAY-598 jẹ ohun elo ti o lagbara, peptide-ifigagbaga kemikali fun SMYD2. BAY-598 ni chemotype alailẹgbẹ ti o ni ibatan si iwadii kemikali SMYD2 lọwọlọwọ LLY-507. BAY-598 ṣe idiwọ in vitro methylation ti p53K370 pẹlu IC50 = 27 nM ati pe o ni diẹ sii ju 100-fold selectivity lori awọn miiran methyltransferases histone ati awọn miiran ti kii-epigenetic afojusun. BAY-598 ṣe idiwọ methylation ti p53K370 ninu awọn sẹẹli pẹlu IC50<1µM. (Siwaju si eyi, BAY-598 ni awọn ohun-ini ti o ni ibamu pẹlu awọn idanwo vivo.) Apo iṣakoso, BAY-369, tun ti ni idagbasoke. BAY-369 ṣe idiwọ methylation in vitro ti p53K370 pẹlu IC50>70 micromolar.
Àfojúsùn:
