I-AZD-5069
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
N-(2-((2,3-difluorobenzyl)thio)-6-((((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
Ikhowudi yoncumo:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Ikhowudi ye-InChi:
InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3,(H,21,22,23)/t11-,14+/m1/s1
Isitshixo se-InChi:
QZECRCLSIGFCIO-RISCZKNCSA-N
Igama elingundoqo:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-AZD-5069 ngumchasi onamandla kwaye okhethiweyo weCXCR2 onamandla okuthintela ukufuduka kwe-neutrophil kwi-airways kwizigulane ezineCOPD. I-AZD-5069 iboniswe ukuba inqanda ukubopha i-CXCL8 ene-radiolabeled kumntu weCXCR2 enexabiso le-pIC50 le-9.1. Ngaphezu koko, i-AZD5069 inhibited neutrophil chemotaxis, kunye ne-pA2 malunga ne-9.6, kunye nokubonakaliswa kwe-molecule ye-adhesion, kunye ne-pA2 ye-6.9, ekuphenduleni i-CXCL1. I-AZD5069 yayingumchasi oguquka ngokukhawuleza weCXCR2 kunye nemiphumo yexesha kunye nobushushu obubonakalayo kwi-pharmacology kunye ne-kinetics ebophelelayo. I-AZD-5069 inokuba luncedo kwisigulane kwiimeko ezivuthayo.
Ithagethi:CXCR2