TH-302; Evofosfamide
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 360 |
| 1g | Ikhona evenkileni | 1000 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
Ikhowudi yoncumo:
O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C
Ikhowudi ye-InChi:
InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)
Isitshixo se-InChi:
UGJWRPJDTDGERK-UHFFFAOYSA-N
Igama elingundoqo:
TH-302, TH302, TH 302, Evofosfamide, 918633-87-1
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-Evofosfamide, eyaziwa ngokuba yi-TH-302, yi-hypoxia-activated prodrug equka i-2-nitroimidazole phosphoramidate conjugate kunye nomsebenzi onokuthi ube ne-antineoplastic. I-2-nitroimidazole moiety ye-hypoxia-activated prodrug TH-302 isebenza njenge-hypoxic trigger, ikhupha i-DNA-alkylating dibromo isophosphoramide mustard moiety ngaphakathi kwemimandla ye-hypoxic yamathumba. Izicubu ze-Normoxic zinokuthi zigcinwe ngenxa ye-hypoxia-specific activity of this agent, inokunciphisa i-systemic toxicity. Khangela izilingo zeklinikhi ezisebenzayo okanye izilingo zekliniki ezivaliweyo usebenzisa le arhente. (NCI).
Ithagethi: DNA Alkylating Agent
