BI-847325
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 400 |
| 500mg | Ikhona evenkileni | 950 |
| 1g | Ikhona evenkileni | 1400 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
Ikhowudi yoncumo:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4
Ikhowudi ye-InChi:
InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2, 1-3H3,(H,30,34)(H,32,35)/b28-27-
Isitshixo se-InChi:
FLBNLJLONKAPLR-DQSJHHFOSA-N
Igama elingundoqo:
BI-847325, BI847325, BI 847325, 1207293-36-4
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-BI-847325 i-BEK / Aurora kinase inhibitor ekhethiweyo kunye ne-IC50 ixabiso le-3, i-25, i-15, i-25, kunye ne-4 nM ye-X. laevis Aurora B, i-Aurora A kunye ne-Aurora C, kunye ne-MEK1 yabantu kunye ne-MEK2, ngokulandelanayo. Inokuthintela ukukhula kunye nokusinda kwayo yomibini imigca yeseli ye-melanoma enganyangekiyo kunyango kunye neyeza, inciphisa ukubonakaliswa kwe-MEK kunye ne-Mcl-1 ngelixa inyusa ukubonakaliswa kweprotein ye-pro-apoptotic Bim. Kwi-70 mg / kg, i-BI-847325 yenza i-apoptosis kunyango-naive kunye neyeza-resistant xenografted melanoma in vivo.
Ithagethi: MEK/Aurora
