GDC-0326

Igama leMchiza:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)oxy)propanamide

Ikhowudi yoncumo:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Ikhowudi ye-InChi:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3) )17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/ m0/s1

Isitshixo se-InChi:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Igama elingundoqo:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-GDC-0326 yi-inhibitor enamandla kwaye ekhethiweyo ye-α-Isoform ye-Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). I-GDC-0326 ifikelela kwinqanaba eliphezulu kakhulu lokukhetha ngaphezu kwezinye i-kinases. I-GDC-0326 ine-plasma ephantsi ye-CL emntwini. Ngaphakathi kwintsapho ye-PI3 kinase, kukho iiklasi ezine ze-I PI3K isoforms (α, β, δ, kunye ne-γ). Kwezi isoforms, i-PI3Kα yeyona nto ixhaphake ngokunxulunyaniswa nomhlaza.

Ithagethi: PI3K