I-AMG-510
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 1g | ikhona evenkileni | 1300 |
| 5g | ikhona evenkileni | 6000 |
| 10g | ikhona evenkileni | 10500 |
Igama leMchiza:
4-((S) -4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl) )pyrido[2,3-d]pyrimidin-2(1H)-enye
Ikhowudi yoncumo:
O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4)=O)CC1
Ikhowudi ye-InChi:
InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22(24)39)34 -29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1 ,12-13,15H2,2-5H3/t18-/m0/s1
Isitshixo se-InChi:
NXQKSXLFSAEQCZ-SFHVURJKSA-N
Igama elingundoqo:
I-AMG-510; I-AMG 510; AMG510
Ukunyibilika:
Ugcino:
Inkcazo:
I-AMG-510 yi-KRAS G12C i-covalent inhibitor enamandla. I-AMG-510 ijolise ngokukhethekileyo kwi-KRAS p.G12C eguqukileyo, nokuba yi-DNA, i-RNA okanye inqanaba leprotheyini, kwaye inqanda, ngendlela engekacaciswanga, ukubonakaliswa kunye/okanye ukubonakaliswa kweseli yethumba nge-KRAS p.G12C eguqukileyo. Oku kunokuthintela ukukhula kwi-KRAS p.G12C-ebonisa iiseli zethumba
Ithagethi: KRAS
