I-AZD8186

Igama leMchiza:

(R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

Ikhowudi yoncumo:

O=C(N(C)C)C1=CC([C@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

Ikhowudi ye-InChi:

InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3 )9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14 -/m1/s1

Isitshixo se-InChi:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Igama elingundoqo:

AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-AZD8186 kunye ne-inhibitor ye-beta isoform ye-phosphoinositide-3 kinase (PI3K), kunye nomsebenzi onokuthi ube ne-antineoplastic. Ekulawuleni, i-PI3Kbeta inhibitor AZD8186 inqanda ngokukhethekileyo umsebenzi we-PI3Kbeta kwindlela yokubonisa i-PI3K/Akt/mTOR, enokubangela ukuhla kwe-tumor cell proliferation. Ikwabangela ukufa kweeseli kwi-PI3K-ebonisa iiseli zomhlaza. Ngokujolisa ngokukodwa kwiklasi ye-I PI3K beta, le arhente inokuthi isebenze ngakumbi kwaye ibe netyhefu encinci kune-pan PI3K inhibitors. I-PI3K-mediated signing ihlala idityaniswa kwiiseli zomhlaza kwaye inegalelo ekwandeni kweseli yethumba, ukusinda, kunye nokuxhathisa ithumba kwiintlobo ezahlukeneyo ze-antineoplastic agents. I-AZD8186 okwangoku iphantsi kolingo lwezonyango lweSigaba soku-I.

Ithagethi: PI3K