Zidesamtinib; NVL-520

Jina la Kemikali:

(6R)-22-ethyl-54-fluoro-42,6-dimethyl-22H,42 H-7-oxa1(3,5)-pyridina-2(3,4)-pyrazola-4(4,5)- [1,2,3]triazola5(1,2)-benzenacycloheptaphan-16-amine

Msimbo wa SMILES:

FC1=CC([C@](OC2=C(N=CC3=C2)N)(C)[H])=C(C=C1)C4=NN(N=C4CC5=C3N(N=C5)CC )C

Msimbo wa InChi:

InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9- 17 (16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25) /t12-/m1/s1

Ufunguo wa InChi:

DTWUUAFTYSMNQX-GFCCVEGCSA-N

Neno muhimu:

2739829-00-4;CAS:2739829-00-4;CAS:2739829-00-4;Zidesamtinib; NVL-520; NVL520; NVL 520

Umumunyifu: 

Hifadhi:Kavu, giza na kwa 0 - 4 C kwa muda mfupi (siku hadi wiki) au -20 C kwa muda mrefu (miezi hadi miaka).

Maelezo:

Zidesamtinib (NVL-520) ni kizuizi chenye ufanisi, kinachoteua, kinachofanya kazi kwa mdomo, na kizuia damu-ubongo kinachoweza kupenyeza muunganisho wa ROS1 na kizuia mabadiliko ya upinzani.

Lengo: ROS1