S-600918，Sivopixant

Jina la Kemikali:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl] -2-methylpropanoic acid

Msimbo wa SMILES:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Msimbo wa InChi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

Ufunguo wa InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Neno muhimu:

2414285-40-6; CAS:2414285-40-6; CAS:2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Umumunyifu:Mumunyifu katika DMSO

Hifadhi:Kavu, giza na kwa 0 - 4 C kwa muda mfupi (siku hadi wiki) au -20 C kwa muda mrefu (miezi hadi miaka)

Maelezo:

Sivopixant, pia inajulikana kama S-600918, ni mpinzani teule wa kipokezi cha P2X3 (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Sivopixant ilionyesha athari kali ya kutuliza maumivu katika mfano wa kuunganisha ujasiri wa siatiki wa panya (mfano wa Seltzer) wa allodynia (ED50, 0.4 mg/kg).

Lengo: mpinzani wa kipokezi cha P2X3