PCO371

Jina la Kemikali:

1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl )sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione

Msimbo wa SMILES:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F )C=C4)N5)C5=O)=O)C(C)=C2)=O

Msimbo wa InChi:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30, 31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)

Ufunguo wa InChi:

LTZJFVOUPUFOHX-UHFFFAOYSA-N

Neno muhimu:

PCO371; PCO-371; PCO 371

Umumunyifu: 

Hifadhi: 

Maelezo:

PCO371 ni agonisti mwenye nguvu na anayechagua PTHR1 kwa matibabu ya hypoparathyroidism. Utawala wa mdomo wa PCO371 kwa panya za osteopenic husababisha ongezeko kubwa la mauzo ya mfupa na ongezeko ndogo la mfupa. Katika panya za hypocalcemic, PCO371 hurejesha viwango vya kalsiamu ya serum bila kuongeza kalsiamu ya mkojo, na kwa madhara yenye nguvu na ya muda mrefu kuliko sindano za PTH.

Lengo: PTHR1