IACS-010759
Maelezo ya Bidhaa
Lebo za Bidhaa
| Ukubwa wa Pakiti | Upatikanaji | Bei (USD) |
| 100 mg | Katika Hisa | 300 |
| 500 mg | Katika Hisa | 800 |
| 1g | Katika Hisa | 1200 |
| Ukubwa Zaidi | Pata Nukuu | Pata Nukuu |
Jina la Kemikali:
5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) phenyl)-1,2,4-oxadiazole
Msimbo wa SMILES:
FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC)N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1
Msimbo wa InChi:
InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3
Ufunguo wa InChi:
HWJWNWZJUYCGKV-UHFFFAOYSA-N
Neno muhimu:
IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4
Umumunyifu:Mumunyifu katika DMSO
Hifadhi:0 - 4 ° C kwa muda mfupi (siku hadi wiki), au -20 ° C kwa muda mrefu (miezi).
Maelezo:
IACS-010759 au IACS-10759 ni Kizuizi chenye nguvu na teule cha Oxidative Phosphorylation (IC50).< 10 nM) yenye shughuli zinazowezekana za antineoplastic. IACS-010759 hufunga na kuzuia changamano I ya mnyororo wa usafirishaji wa elektroni (NADH ubiquinone oxidoreductase), na hivyo kwa kuchagua hunyima seli za tumor ya virutubisho, na nishati, na kuzuia utengenezaji wa nyukleotidi na asidi ya amino, ambayo husababisha autophagy, husababisha kifo cha seli ya tumor na kuzuia seli. kuenea. Mitochondrial tata I, ambayo imechanganyikiwa katika seli za saratani ili kukidhi mahitaji yao ya kuongezeka kwa nishati, ina jukumu muhimu katika kukuza kuenea kwa seli za saratani.
Lengo: OXPHOS