TAS-120

Lebitso la lik'hemik'hale:

1- [(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl) ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl] -1-pyrrolidinyl] -2-propen-1-one

SMILES Khouto:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

Khoutu ea InChi:

InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5 -14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23, 24,25)/t15-/m0/s1

InChi Key:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Keyword:

TAS-120

Sollubility: 

Polokelo: 

Tlhaloso:

TAS-120 ke inhibitor ea molomo ea bioavailable ea fibroblast growth factor receptor (FGFR) e nang le ts'ebetso e ka bang teng ea antineoplastic. FGFR inhibitor TAS-120 ka boikhethelo le ka mokhoa o ke keng oa fetoloa e tlama le ho thibela FGFR, e ka 'nang ea fella ka ho thibela tsela ea phetisetso ea matšoao a mabeli a FGFR le ho ata ha lisele tsa tumor, le ho eketsa lefu la lisele ho FGFR-overexpressing lisele tsa tumor. FGFR ke receptor tyrosine kinase e hlokahalang bakeng sa ho ata ha lisele tsa tumor, ho arohana le ho phela 'me polelo ea eona e laoloa ke mefuta e mengata ea lisele tsa tumor.

Sepheo: FGFR