AZD-5069
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
SMILES Khouto:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Khoutu ea InChi:
InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3,(H,21,22,23)/t11-,14+/m1/s1
InChi Key:
QZECRCLSIGFCIO-RISCZKNCSA-N
Keyword:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
AZD-5069 ke mohanyetsi ea matla le ea khethileng oa CXCR2 ea nang le bokhoni ba ho thibela ho falla ha neutrophil ho ea ho moea ho bakuli ba COPD. AZD-5069 e bontšitsoe ho thibela ho tlama ha CXCL8 ea radiolabeled ho motho CXCR2 ka boleng ba pIC50 ba 9.1. Ho feta moo, AZD5069 e thibelitse neutrophil chemotaxis, e nang le pA2 e ka bang 9.6, le polelo ea molek'hule ea adhesion, e nang le pA2 ea 6.9, ho arabela CXCL1. AZD5069 e ne e le mohanyetsi ea fetohang butle-butle oa CXCR2 ka liphello tsa nako le mocheso tse bonahalang ho pharmacology le kinetics e tlamang. AZD-5069 e boetse e ka thusa mokuli maemong a ho ruruha.
Sepheo: CXCR2