EAI-045

EAI-045
  • Lebitso:EAI-045
  • Nomoro ea lethathamo:CPDB0934
  • Nomoro ea CAS:1942114-09-1
  • Boima ba Molek'hule:383.4
  • Foromo ea Lik'hemik'hale:Setšoantšo sa C19H14FN3O3S
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    Lebitso la lik'hemik'hale:

    2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

    SMILES Khouto:

    O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

    Khoutu ea InChi:

    InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8 -27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

    InChi Key:

    YTUFHOKUFOQRDF-UHFFFAOYSA-N

    Keyword:

    EAI-045, EAI045, EAI 045, 1942114-09-1

    Sollubility:E qhibiliha ka DMSO

    Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)

    Tlhaloso:

    EAI045 e matla le e khethang ea EGFR inhbitor. EAI045 e ikemiselitse ho khetha liphetoho tsa EGFR tse hananang le lithethefatsi empa e boloka moamoheli oa mofuta o hlaha. EAI045 e thibela EGFR ea L858R/T790M-mutant e nang le matla a tlase a nanomolar litekong tsa biochemical.

    Sepheo: EGFR


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