MSC2530818

Magaca Kiimikada:

[(2S)-2- (4-Chlorophenyl) pyrrolidin-1-yl] (3-methyl-1H-pyrazolo [3,4-b] pyridin-5-yl) methanone

Koodhka dhoola cadeynta:

O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3

Koodhka InChi:

InChi=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4- 6-14 (19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1

Furaha InChi:

ODRITQGYYWHQGM-INIZCTEOSA-N

Ereyga muhiimka ah:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

MSC2530818 waa Awood, Xulasho, iyo Af-ka-soo-baxa Bioavailable CDK8 Inhibitor leh CDK8 IC50 = 2.6 nM; Saadaasha PK ee aadanaha: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. MSC2530818 waxay soo bandhigaysaa xulashada kinase aad u wanaagsan, biochemical iyo awoodda gacanta, xasilloonida microsomal, oo afka waa noolaha. MSC2530818 waxay muujisaa awoodda ku habboon iyo xulashada si loogu hormaro daawaynta saxda ah ee waxtarka iyo amniga vivo.

Ujeedka: CDK