NTN21277

Magaca Kiimikada:

(2S,4R)-1-((S)-2-(3-(2-)-((5-(5-(4-(3-chloro-4-fluorophenyl))))-7-methoxyquinazolin-6-yl) oxy) pentyl) oxy) ethoxy) propanamido) -3,3-dimethylbutanoyl)-4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide

Koodhka dhoola cadeynta:

O=C ([C@H] 1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C ==O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Koodhka InChi:

InChi=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-3 3(57)26-56(38)46(60)43(47(2,3)4)55-41 (58)15-18-63-20-19-62-16-7-6-8- 17-64-40-23-34-37 (24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24 ,27-28,33,3 8,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33- ,38+,43-/m1/s1

Furaha InChi:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Ereyga muhiimka ah:

PROTAC ku salaysan Gefitinib; NTN21277; NTN-21277; NTN 21277

Xalka: 

Kaydinta: 

Sharaxaad:

NTN21277, oo sidoo kale loo yaqaan Gefitinib-based PROTAC 3 waa VHL-qorista PROTAC taas oo keenta hoos u dhaca EGFR iyo EGFR mutants oo leh DC50 ee 11.7 nM iyo 22.3 nM ee unugyada HCC827 (Exon 19 del) iyo unugga H3258R (L).

Hadafka: EGFR