JBJ-04-125-02 R-isomer
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
Magaca Kiimikada:
(R) -2- (5-fluoro-2-hydroxyphenyl) -2- (1-oxo-6-- (4- (piperazin-1-yl) phenyl) isoindolin-2-yl)-N-(thiazol-2) -yl) acetamide
Koodhka dhoola cadeynta:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Koodhka InChi:
InChi=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19 (15-23 (20)28 (35)38)18-3-6-22 (7-4-18)34-12-9-31-10-13-34/h1-8, 11,14-16,26,31,36H,9-10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
Furaha InChi:
VHQVOTINPRYDAO-AREMUKBSSA-N
Ereyga muhiimka ah:
Xalka:
Kaydinta:
Sharaxaad:
JBJ-04-125-02 waa mutant-doortay EGFR allosteric inhibitor oo leh firfircoonida ka hortagga kansarka. Sida hal wakiil, waxay joojin kartaa kororka unugyada iyo EGFRL858R/T790M/C797S calaamadaynta in vitro iyo in vivo. Isku darka osimertinib iyo JBJ-04-125-02 waxay keenaysaa kororka apoptosis, xannibaad waxtar leh oo korriinka gacanta ah, iyo kor u kaca waxtarka vitro iyo in vivo marka la barbar dhigo mid ka mid ah wakiilka keligiis.
Hadafka: EGFR
