AZD-3409

Magaca Kiimikada:

(S) -isopropyl 2- (2- (4-fluorophenethyl) -5-(((2S,4S) -4- (nicotinoylthio) pyrrolidin-2-yl) methyl) amino) benzamido) -4- (methylthio) butanoate

Koodhka dhoola cadeynta:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Koodhka InChi:

InChi=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30 -18-27(13-10-24(30)9-6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38 -28)45-34 (42)25-5-4-15-36-19-25/h4-5,7-8,10-13,15,18-19,22,28-29, 31,37-38H,6,9,14,16-17,20-21H2,1-3H3,(H,39,40)/t28-,29-,31-/m0/s1

Furaha InChi:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Ereyga muhiimka ah:

AZD3409; AZD-3409; AZD 3409

Xalka: 

Kaydinta: 

Sharaxaad:

AZD-3409 waa ka hortag awood badan oo prenyl transferase. AZD-3409 waxay muujisay awood ka sareysa lonafarnib. Celceliska IC (50) ee cytotoxicity ee AZD3409 waxay ahayd 510 ee unugyada MEF, 10,600 ee unugyada A549 iyo 6,170 ee unugyada MCF7, siday u kala horreeyaan. Unugyadaan, IC (50) ee waxqabadka FTase ee AZD3409 waxay u dhaxaysaa 3.0 ilaa 14.2 nM iyo lonafarnib laga bilaabo 0.26 ilaa 31.3 nM. AZD3409 waxay joojisaa farnesylation ilaa xad ka sarreeya geranylgeranylation. Joojinta farnesylation iyo geranylgeranylation labadaba lama xiriirin karo waxqabadka ka hortagga faafinta ee daroogada. AZD3409 waxa laga yaabaa inay ku firfircoonaato kansarka naasaha u adkaysta gefitinib.

Bartilmaameedka: prenyl transferase inhibitor