GLPG0187

Magaca Kiimikada:

(S)-3-((2,5-dimethyl-6--4- (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl)amino)-2-((4-methoxyphenyl)sulfonamido)propanoic acid

Koodhka dhoola cadeynta:

O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5=O

Koodhka InChi:

InChi=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23 32-19 (2)33-28 (18)36-15-12-20 (13-16-36)24-11-6-21-5-4-14-30-27(21)34-24/ h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0 /s1

Furaha InChi:

CXHCNOMGODVIKB-VWLOTQADSA-N

Ereyga muhiimka ah:

GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

Qiimaynta wejiga adag, GLPG0187 waxay muujinaysaa xulashada dhowr receptors RGD integrin oo leh IC50s ee 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM ee αvβ1, αvβ3, αvβ5, αvβ,6, αvβ8 GLPG0187 waa horjooge awood leh oo dib u soo celinta lafaha osteoclastic iyo angiogenesis. Daawaynta qiyaasta GLPG0187-ku-tiirsanaanta waxay kordhisaa saamiga E-cadherin/vimentin, taasoo ka dhigaysa unugyada epithelial badan, phenotype sessile. Qiyaasta GLPG0187-ku-tiirsanaanta waxay yaraynaysaa cabbirka aldehyde dehydrogenase tirada sare ee unugyada kansarka qanjirka 'prostate'[1]. Daawaynta GLPG0187 waxay keentaa isku-duubnida unugyada iyo isku-duubnida. GLPG0187 waxay muujinaysaa hoos u dhac weyn oo ku-tiirsanaanta qiyaasta u guuritaanka unugyada burooyinka. GLPG0187 marka la eego dhammaan uruurinta waxay si weyn u yaraynaysaa kororka unugyada[2].

Bartilmaameedka: αvβ1