IT-901

Magaca Kiimikada:

5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H) -pyrimidinedione

Koodhka dhoola cadeynta:

O=C(/C(C(N1)=O)=CC2=C3C=CC=CC3=C(OC)C=C2OC)NC1=S

Koodhka InChi:

InChi=1S/C17H14N2O4S/c1-22-13-8-14(23-2)11(9-5-3-4-6-10(9)13)7-12-15(20)18-17 24)19-16 (12)21/h3-8H,1-2H3,(H2,18,19,20,21,24)

Furaha InChi:

JHOPCCOYRKEHQU-UHFFFAOYSA-N

Ereyga muhiimka ah:

IT-901, IT901, IT 901, 1584121-99-2

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

"IT-901 waa c-Rel Inhibitor kaas oo dhexdhexaadiya sifooyinka Kansarka ee Dhiig-baxa Dhiig-baxa iyadoo la xakameynayo NF-κB-Controlled Oxidative Stress Responses. IT-901 waxay si xooggan u xakameysaa NF-κB qaybteeda c-Rel. IT-901 oo la xakameynayo tallaalka-ka-horjeedka- Cudurka martida loo yahay iyada oo la ilaalinayo dhaqdhaqaaqa-ka-hortagga-lymphoma inta lagu jiro tallaalka allogeneic ee dheeraadka ah ee IT-901 ee daaweynta lymphoma B-cell ayaa shaaca ka qaaday sifooyinka antitumor ee vitro iyo in vivo iyada oo aan la xaddidin NF-κB-ku-tiirsanaanta IT-. 901 kama aysan soo saarin heerarka korodhka ah ee noocyada oksijiinta ee leukocytes caadiga ah, oo muujinaya sifooyinkeeda xulashada kansarka IT-901 waa wakiilka daweynta cusub ee lagu daweeyo burooyinka lymphoid ee bini'aadamka iyo hagaajinta cudurka.

Hadafka: NF-kB