RGX-104 HCl

Magaca Kiimikada:

(R) -2-[3-[3-[[2-Chloro-3- (trifluoromethyl) benzyl] (2,2-diphenylethyl) amino]-3-methylpropoxy] phenyl] acetic acid hydrochloride.

Koodhka dhoola cadeynta:

O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl

Koodhka InChi:

InChi=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31 /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1

Furaha InChi:

LCMIYQOJZLRHTO-GJFSDDNBSA-N

Ereyga muhiimka ah:

RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

RGX-104 waa beerka X reseptor beta agonist oo leh waxqabadyo immunomodulating iyo antineoplastic suurtagal ah. Marka la maamulo afka, RGX-104 waxay si xushmad leh u bartilmaameedsanaysaa oo waxay ku xidhaysaa LXRbeta, si ay u hawlgeliso calaamadinta dhexdhexaadinta LXRbeta, taasoo horseedaysa qoritaanka hiddo-wadaha xakamaynta burooyinka qaarkood iyo hoos u dhigista hiddo-wadaha dhiirrigeliyaha burooyinka qaarkood. Tani waxay si gaar ah u dhaqaajisaa muujinta apolipoprotein E (ApoE), borotiinka xakameynaya burooyinka, unugyada burooyinka iyo unugyada difaaca qaarkood. Tani waxay kicisaa habka difaaca gudaha, taasoo keentay hoos u dhaca unugyada difaaca jirka ee myeloid-derived immunosuppressive (MDSCs), unugyada burooyinka iyo unugyada endothelial ee ku jira microenvironment burooyinka. Tani waxay beddeshaa ka-baxsanaanta difaaca, waxay xoojisaa jawaab-celinta difaaca-ka-hortagga buro waxayna joojisaa kororka unugyada burooyinka.

Ujeedka: LXRbeta