BLU-285
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 1g | In stock | 900 |
| 5g | In stock | 3600 |
| 10g | In stock | 6200 |
| Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
(S)-1- (4-fluorophenyl) -1- (2- (4---6-- 1-methyl-1H-pyrazol-4-yl) pyrrolo [2,1-f] [1,2,4] ]triazin-4-yl) piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine
Koodhka dhoola cadeynta:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C) N3)=C2)=C1
Koodhka InChi:
InChi=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)2 4-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2, 1-2H3/t26-/m0/s1
Furaha InChi:
DWYRIWUZIJHQKQ-SANMLTNESA-N
Ereyga muhiimka ah:
BLU-285, BLU 285, BLU285, Avapritinib
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).
Sharaxaad:
Avapritinib (BLU-285) waxay muujisay firfircoonida biochemical in vitro ee KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Dhaqdhaqaaqa gacanta ee Avapritinib ee ku jira KIT D816 mutants waxaa lagu qiyaasaa autophosphorylation ee khadka unugyada leukemia ee unugyada leukemia HMC1.2, iyo P815 mouse mastocytoma cell line IC50 = 4 iyo 22 nM, siday u kala horreeyaan. Unugyada Kasumi-1, at (8; 21) -khadka unugyada AML togan oo leh KIT exon 17 N822K mutation, Avapritinib si xoog leh u joojiso KIT N822K mutant autophosphorylation (IC50 = 40 nM), calaamadaynta hoose, iyo sidoo kale kordhinta gacanta (IC50= 75 nM)[1].
Ujeedka: KIT
