BLU-9931
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 100mg | In stock | 220 |
| 300mg | In stock | 500 |
| 1g | In stock | 1350 |
| Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
N-(2-(6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl) acrylamide
Koodhka dhoola cadeynta:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
Koodhka InChi:
InChi=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-) 17 (16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33) (H,29,31,32)
Furaha InChi:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Ereyga muhiimka ah:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).
Sharaxaad:
Unugyada MDA-MB-453, BLU9931 waxay si xoog leh u joojisaa fosforyaalka jidka calaamadaynta FGFR4. BLU9931 waxay xakameysaa fidinta xadhkaha unugyada HCC ee muujiya calaamadaynta FGFR4 ee sugan, sida Hep 3B, HUH-7, iyo JHH-7 khadadka unugyada, oo leh EC50 of<1 μM. BLU9931 waxay sidoo kale joojisaa fidinta xariiqyada unugyada PDX ee leh dariiqa calaamadaha FGFR4 oo sugan[1]. BLU9931 waxay keentaa burada oo yaraada moodooyinka kansarka hepatocellular kuwaas oo muujinaya isku xidhka ligand/receptor ka kooban FGF19/FGFR4/KLB oo ku dara liiska sii kordhaya ee wakiilada anti-FGFR4[2].
Ujeedka: FGFR4
