EED226

Magaca Kiimikada:

N- (furan-2-ylmethyl) -8- (4- (methylsulfonyl) phenyl)-[1,2,4]triazolo [4,3-c] pyrimidin-5-amine

Koodhka dhoola cadeynta:

O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

Koodhka InChi:

InChi=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-1) 1-20-21-16 (15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

Furaha InChi:

DYIRSNMPIZZNBK-UHFFFAOYSA-N

Ereyga muhiimka ah:

EED226, EED-226, EED 226, 2083627-02-3

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

EED226 waa mid aad u awood badan, wax ku ool ah oo xakameynaya EZH2 iyo EZH1 oo lagu qiimeeyay tiro balaadhan oo ah bartilmaameedyada epigenetic iyo non-epigenetic. Waxay si xoog leh u yaraynaysaa calaamadda caalamiga ah ee H3K27Me3 ee unugyada waxayna muujisaa saamaynta dilida unugga ee xulashada unugyada sidda isbeddellada heterozygous Y641N. EED226 waxay leedahay dhex-dhexaad dhexdhexaad ah sida lagu qiyaaso unugyada Caco-2 ee A → B = 3.0x10-6 cm / s, oo leh saamiga dheecaanka ee 7.6[1].

Ujeedka: EED226