BAY-598

Chemical Name:

(S,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol- 4-yl)-N-ethyl-2-hydroxyacetamide

SMILES Kodhi:

CCN(C(CO)=O)[C@H]1CN(/C(NC2=CC=CC(OC(F)F)=C2)=N/C#N)N=C1C3=CC(Cl)= C(Cl)C=C3

InChi Code:

InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22(28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3, (H,28,29)/t18-/m0/s1

InChi Key:

OTTJIRVZJJGFTK-SFHVURJKSA-N

Keyword:

BAY-598; BAY 598; BAY598

Solubility:DMSO

Kuchengeta: 

Tsanangudzo:

BAY-598 ine simba, peptide-inokwikwidza kemikari probe ye SMYD2. BAY-598 ine yakasarudzika chemotype inoenderana neyazvino SMYD2 kemikari probe LLY-507. BAY-598 inhibits in vitro methylation yep53K370 ine IC50 = 27 nM uye ine zvinopfuura 100-fold selectivity pane mamwe histone methyltransferases uye zvimwe zvisiri epigenetic zvinangwa. BAY-598 inhibits the methylation yep53K370 mumaseru ane IC50.<1 µM. (Kuenderera mberi neizvi, BAY-598 ine zvivakwa zvinofambirana nezviyedzo zve vivo.) Mushonga wekutonga, BAY-369, wakagadzirwawo. BAY-369 inhibits iyo in vitro methylation yep53K370 ine IC50 >70 micromolar.

Chinangwa: makemikari probe ye SMYD2