PCO371

Chemical Name:

1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione

SMILES Kodhi:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F )C=C4)N5)C5=O)=O)C(C)=C2)=O

InChi Code:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30, 31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)

InChi Key:

LTZJFVOUPUFOHX-UHFFFAOYSA-N

Keyword:

PCO371; PCO-371; PCO 371

Solubility: 

Kuchengeta: 

Tsanangudzo:

PCO371 ine simba uye inosarudza PTHR1 agonist yekurapa hypoparathyroidism. Oral administration yePCO371 kune osteopenic rats inokonzera kuwedzera kukuru kwekuchinja kwemapfupa nekuwedzera kushoma kwefupa. Mune hypocalcemic rats, PCO371 inodzorera serum calcium mazinga pasina kuwedzera urinary calcium, uye nemigumisiro yakasimba uye inogara kwenguva refu kupfuura PTH jekiseni.

Chinangwa: PTHR1