PCO371

Igoa vaila'au:

1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl )sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione

SMILES Code:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F)F )C=C4)N5)C5=O)=O)C(C)=C2)=O

InChi Code:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11 -13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9 -14H2,1-4H3,(H,33,35,39)(H,34,38,40)

InChi Key:

LDZJFVOUPUFOHX-UHFFFAOYSA-N

upu autu:

PCO371; PCO-371; PCO 371

Solubility: 

Teuina: 

Fa'amatalaga:

PCO371 o se agonist PTHR1 malosi ma filifilia mo togafitiga o le hypoparathyroidism. O le tu'u gutu o le PCO371 i isumu o le osteopenic e fa'aosoina ai se fa'atuputeleina tele o le suiga o ponaivi ma fa'atapula'aina le fa'ateleina o ponaivi. I isumu hypocalcemic, PCO371 toe faʻafoʻisia le maualuga o le calcium toto e aunoa ma le faʻateleina o le calcium urinary, ma faʻatasi ai ma aʻafiaga malosi ma umi atu nai lo tui PTH.

Sini: PTHR1